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CHIMEX CURCUMA PROFESSIONAL

The antiplasmodial activity and safety of Cur-PLGA was better at lower concentration. At higher concentrations (1000 and 500 μg/mL), Cur-PLGA entrapped nanoparticle showed higher toxicity compared with the free drug ( p 0.05). The percentage parasite suppression (56.8%) at 5 mg/kg was significantly higher than in free drug (40.5%) of similar concentration ( p 0.05) except in lymphocytes which were significantly higher in Cur-PLGA compared to the free drug ( p 0.05). The size and entrapment efficiency of the nanoparticulate drug formulated was 291.2 ± 82.1 nm and 21.8 ± 0.4 respectively. In vitro cytotoxicity of free and PLGA encapsulated curcumin (Cur-PLGA) to RAW 264.7 cell line was also determined at varying concentrations (1000–7.8 μg/mL).

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In vivo anti-parasitic test and toxicity assays for free and encapsulated drug were performed at 5 and 10 mg/kg. Hematological and hepatic toxicity assays were performed on whole blood and plasma, respectively. The nanoparticles were characterized and evaluated in vivo for antimalarial activities using Peter’s 4-day suppressive protocol in mice model. Curcumin was loaded with poly ( D,L-lactic-co-glycolic acid) (PLGA) using solvent evaporation from oil-in-water single emulsion method. This study aimed to evaluate the in vivo antiplasmodial activity and the toxicity assessment of curcumin incorporated into poly (lactic-co-glycolic) acid (PLGA) nanoparticles. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem.

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4Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, IndiaĬurcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine.3Product Development Cell, National Institute of Immunology, New Delhi, India.

2Department of Biological Sciences, University of Medical Sciences, Ondo, Nigeria.

1Department of Zoology, University of Ibadan, Ibadan, Nigeria.

Oyeyemi 2,3*, Jairam Meena 3, Debasis Sahu 3,4 and Amulya K. Morenikeji 1*, Funmilayo Afolayan 1, Oyetunde T.

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